Fixed-layout ebooks are a lot like PDFs: everything has to have a fixed place. They are designed with a specific device in mind and don't display well on all devices.
A fixed layout might be necessary for textbooks, but is a no-go for fiction. Amazon only accepts fixed-layout ebooks in the following categories: reference books, comic books, and children's books. It is also important to note that while Amazon requires EPUB format for all books now, this still does not apply to fixed layout ebooks. If you have a fixed layout book, please upload a MOBI file.
Barnes and Noble only accept fixed layout ebooks if they are children's books.
The following stores accept fixed layout ebooks: Amazon (special terms: mentioned above), Apple, Google, Scribd, Libby, CNPIEC, Dangdang, Gardners, Mackin, Bibliotheca, Kobo, E-sentral, Hungarian stores (Ekonyv.hu, Multimédiapláza, E-letöltés).
The following stores do not accept fixed layout ebooks: 24Symbols, Barnes and Noble (except for children's books), Bookmate, Ciando, Dibook, Dreame, Hoopla, Odilo, Perlego.